apalutamide will reduce the extent or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medication which can be CYP3A4 substrates can lead to reduce exposure to those remedies.If you take codeine to be a liquid, it will